Deconstructing a Full Prescribing Information – Part II Saturday 1/8/11Posted by smcgamer in Archive, Uncategorized.
Tags: deconstruction, postaday2011
Today is Saturday, January 8.
Third Paragraph and Beyond
and the following inactive ingredients: colloidal silicon dioxide, croscarmellose, sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin.
Colloidal silica is an amorphous, non-porous liquid form of silica. It is used in things like paper and tape. Croscarmellose sodium is an “internally cross-linked” sodium carboxymethyl cellulose used as an excipient in pharmaceuticals (it carries the active medication, in this case eszopiclone, through the body faster than the body would normally absorb it).
As for sodium, it’s probably sodium chloride – table salt (or many other forms, such as kosher or rock salt). Hypromellose is a “semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant”. It also functions as an excipient.
Lactose is a disaccharide found in milk and dairy products. Some people have problems digesting it. Magnesium stearate is used as a diluent (filler) and lubrication for the excipient.
Microcrystalline cellulose, on the other hand, is a fancy term for wood pulp. (But, it’s refined!) It can be used as an anti-caking agent and a fat substitute. Polyethylene glycol is “a polyether compound with many applications from industrial manufacturing to medicine.”
Titanium dioxide is a white powder that can be used a pigment and in stuff like sunscreen to food coloring. It’s likely that titanium dioxide it was covers the layer between the film coating and the eszopiclone, giving it a white shine. Triacetin is a food additive, a solvent in flavorings, and used as a humectant (hygroscopic, meaning it attracts water; useful as a desiccant; it probably keeps the pills dry).
Wow, five paragraphs for one sentence. I’m on a roll.
In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.
FD Blue #2 is also called Indigo carmine, and it’s a pH indicator and a colorant. It probably goes on the printing.
There shall be more tomorrow. This late editing schedule is killing me.
- Deconstructing the sounds of Mario (gonintendo.com) (OK, maybe not related.)