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Deconstructing a Full Prescribing Information – Part II Saturday 1/8/11

Posted by smcgamer in Archive, Uncategorized.
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Today is Saturday, January 8.


Third Paragraph and Beyond

and the following inactive ingredients: colloidal silicon dioxide, croscarmellose, sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin.

Colloidal silica is an amorphous, non-porous liquid form of silica.  It is used in things like paper and tape.  Croscarmellose sodium is an “internally cross-linked” sodium carboxymethyl cellulose used as an excipient in pharmaceuticals (it carries the active medication, in this case eszopiclone, through the body faster than the body would normally absorb it).

Making a saline water solution by dissolving t...

Image via Wikipedia

As for sodium, it’s probably sodium chloride – table salt (or many other forms, such as kosher or rock salt).  Hypromellose is a “semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant”.  It also functions as an excipient.

Lactose is a disaccharide found in milk and dairy products.  Some people have problems digesting it.  Magnesium stearate is used as a diluent (filler) and lubrication for the excipient.

Microcrystalline cellulose, on the other hand, is a fancy term for wood pulp.  (But, it’s refined!)  It can be used as an anti-caking agent and a fat substitute.  Polyethylene glycol is “a polyether compound with many applications from industrial manufacturing to medicine.”

titanium(IV) oxide

Image via Wikipedia

Titanium dioxide is a white powder that can be used a pigment and in stuff like sunscreen to food coloring.  It’s likely that titanium dioxide it was covers the layer between the film coating and the eszopiclone, giving it a white shine.  Triacetin is a food additive, a solvent in flavorings, and used as a humectant (hygroscopic, meaning it attracts water; useful as a desiccant; it probably keeps the pills dry).

Wow, five paragraphs for one sentence.  I’m on a roll.

In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

FD Blue #2 is also called Indigo carmine, and it’s a pH indicator and a colorant.  It probably goes on the printing.

There shall be more tomorrow.  This late editing schedule is killing me.


1. Deconstructing A Full Prescribing Information: Part 3 | Smc_Gamer's Blog - Wednesday 1/12/11

[…] of the full text of the full prescribing information of Lunesta.  Please read parts one and two to get up to […]

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