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Deconstructing A Full Prescribing Information: Part 3 Wednesday 1/12/11

Posted by smcgamer in Archive, Deconstucting The.
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Tonight, I’ll continue the deconstruction of the full text of the full prescribing information of Lunesta.  Please read parts one and two to get up to speed.

CLINICAL PHARMACOLOGY

Pharmacodynamics

Pharmacology is the study of medicine’s affect on the body; researching how it works and why.  Pharmacodynamics is “what the drug does to the body”, as said by Leslie Z. Bennet in a medical journal.

The precise mechanism of action of eszopiclone as a hypnotic is unknown,

Well, that’s reassuring.

but its effect is believed to result from its interaction with GABA-receptor complexes

A GABA-receptor is a receptor that responds to gamma-Aminobutryic acid.  They are the chief inhibitory neurotransmitters.

at binding domains located close to or allosterically coupled to benzodiazepine receptors.

A binding domain is a protein domain which binds to an atom or a molecule.  Allosteric regulation is when a regulating molecule binds to a protein to regulate it.  Benzodiazepine is a psychoactive drug.

Eszopiclone is a nonbenzodiazepine hypnotic that is a pyrrolopyrazine derivative of the cyclopyrrolone class

Being nonbenzodiazepine is good, since benzodiazepine appears to be addictive if overused. Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepines similar to benzodiazepines.  So, they work like benzodiazepines, but they are not.

Core structure of the most common pharmacologi...

Image via Wikipedia

with a chemical structure unrelated to pyrazolopyrimidines, imidazopyridines, benzodiazepines, barbiturates, or other drugs with known hypnotic properties.

It’s a new kind of sedative!  All of the above drugs are sedatives.

Next Time: Part IV, introducing the pharmacokinetics of eszopiclone!

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