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Deconstructing a Full Prescribing Information: Part V Sunday 1/16/11

Posted by smcgamer in Archive, Uncategorized.
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Yesterday, I had forgotten to write my post-a-day until it was too late.  To prevent this in future, I’m going to make use of the publish-schedule mode.

Onward with the pharmacokinetics!

Note: For an explanation of pharmacokinetics, as well as a link to the Wikipedia page, please check Thursday’s post.

Metabolism

Following oral administration, eszopiclone is extensively metabolized by oxidation and demethylation.

Oxidation is a chemical reaction, in which atoms have their oxidation number changed.  Demethylation is the removal of a methyl group.  It is often catalyzed by an enzyme such as Cytochrome P450.

Ball-and-stick model of the (S)-zopiclone (esz...

Image via Wikipedia

The primary plasma metabolites are (S)-zopiclone-N-oxide and (S)-N-desmethyl zopiclone; the latter compound binds to GABA receptors with substantially lower potency than eszopiclone, and the former compound shows no significant binding to this receptor.

I’m not feeling good tonight, so I’ll save you the explanation and just link all the stuff.  More will come soon.

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